The Impact of Low Level of High Density Lipoprotein Cholesterol on Adverse Clinical Outcomes in Patients with Mild to Moderate Aortic Stenosis

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The American Journal of Cardiology APRIL 23e26, 2013 AN lipoprotein cholesterol (HDL) is associated with atherosclerosis and known to be a risk factor of cardiovascular disease. However, there have been limited data whether the impact of low HDL on echocardiographic characteristics in patients (pts) with mild to moderate AS. Methods: A total of 241 consecutive pts with mild to moderate AS were enrolled between January 2004 and May 2010. The pts were divided into two groups according to HDL level: Low HDL group (HDL-C<40mg/dl in male and HDL-C < 50mg/dl in female, n1⁄4 408) and control group (n1⁄4391). Baseline clinical and echocardiographic characteristics were compared between two groups. Results: Baseline clinical characteristics were similar between two groups. Echocardiographic data in M-mode and 2D image showed that left ventricle end systolic diameter (LVESD, 29.4 4.5 vs 29.5 3.7, pvalue 1⁄40.006), left ventricle end diastolic diameter (LEDD, 48.2 4.3 vs 45.2 4.4, p-value <0.001), and left ventricle mass index (LVMI, 119.8 30.0 vs 118.2 24.0, p-value 1⁄40.037) were higher in Low HDL group. Doppler echocardiographic data showed that E’ were lower in Low HDL group (0.04 0.01vs 0.05 0.01, p-value 1⁄40.002). However, ejection fraction, left atrium diameter, aortic valve peak velocity and mean pressure gradient were similar between two groups. Pearson correlation analysis by showed that low HDL was not correlated with LVESD (p1⁄40.410), LVEDD (p1⁄40.267), and LVMI (p1⁄40.327). But, low HDL was correlated with aortic valve peak velocity (p1⁄40.024). Conclusion: In this study, Low HDL is associated with LVEDD, LVESD, and LVMI. And low HDL was correlated with aortic valve peak velocity (p1⁄40.024).