The impact of local/regional radiotherapy (RT), and its timing, on survival following lumpectomy/mastectomy and systemic chemotherapy in patients with ≥10 positive axillary nodes: Analysis of CALGB 9082

Abstract

In CALGB 9082, patients with breast cancer involving ≥10 axillary nodes without evidence of distant metastasis received 4 cycles of induction CAF chemo and were then randomized to receive either high dose cyclophosphamide, cisplatin, BCNU with autologous marrow/stem-cell support or intermediate-doses of the same drugs. All patients were prescribed to receive local-regional RT following chemo. We herein assess whether there was an association of overall survival with (1) receipt of RT and (2) the timeliness of RT among irradiated patients.