Abstract
Background and aim Ascites in liver cirrhosis is associated with a poor prognosis and impairment of the quality of life and may be complicated by hepatorenal syndrome. Renal functions and haemodynamic changes after large-volume paracentesis (LVP) in cirrhotic patients with tense ascites were evaluated. Patients and methods A total of 50 cirrhotic patients with tense ascites were divided into two groups: group I 25 patients without renal impairment and group II 25 patients with renal impairment (type II hepatorenal syndrome). Results In groups I and II, the serum creatinine decreased significantly 24 h after LVP (P Conclusion LVP causes a significant reduction of heart rate and mean arterial pressure, serum creatinine, blood urea nitrogen and RI with a significant glomerular filtration rate increase, but had no effect on the plasma renin activity.
Highlights
Hepatorenal syndrome (HRS) is a clinical condition that occurs in patients with chronic liver disease, advanced hepatic failure and portal hypertension due to impaired renal function and marked abnormalities in the arterial circulation and the activity of endogenous vasoactive systems
There is marked renal vasoconstriction that results in a low glomerular filtration rate (GFR), whereas in the extrarenal circulation, there is a predominance of arterial vasodilatation, which results in the reduction of the total systemic vascular resistance and arterial hypotension [1]
This is in agreement with a study conducted by Appenrodt et al [14] who found a significant decrease in the heart rate (HR) 1 and 24 h after paracentesis compared with the baseline HR (80, 76 and 72 beats/min) in cirrhotic patients with ascites
Summary
Hepatorenal syndrome (HRS) is a clinical condition that occurs in patients with chronic liver disease, advanced hepatic failure and portal hypertension due to impaired renal function and marked abnormalities in the arterial circulation and the activity of endogenous vasoactive systems. Renal functions and haemodynamic changes after large-volume paracentesis (LVP) in cirrhotic patients with tense ascites were evaluated. The glomerular filtration rate and the urine output increased significantly 24 h after LVP (P < 0.05, P < 0.01 and P < 0.01, P < 0.05, respectively, in groups I and II). Conclusion LVP causes a significant reduction of heart rate and mean arterial pressure, serum creatinine, blood urea nitrogen and RI with a significant glomerular filtration rate increase, but had no effect on the plasma renin activity
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
