The Impact of Iron Overload Before Transplant and the Natural Evolution of Ferritin After Transplant on Childhood Allogenic SCT

Abstract

Iron overload before hematopoietic stem cell transplantation (HSCT) is known to be associated with non-relapse mortality, infections and sinusoidal obstructive disease (SOS). Therefore some groups reported that iron-chelating therapy before HSCT might improve the outcome. After HSCT most recipients eventually transfusion independent, however more than half of HSCT adult long-term survivors had above normal ferritin level and requirements of iron-chelating therapy for such patients is still controversial.