Abstract
This study purported to investigate the impact of interleukin-10 (IL-10) gene 4 polymorphisms (−1082G>A, -819T>C, -592A>C and 210T>C) on peripheral blood IL-10 variation and prostate cancer (PCa) risk, with a special consideration given to various origins of between-study heterogeneity. 2 researchers independently fulfilled literature retrieval, quality assessment and information collection. Sub-grouped analyses per ethnicity, continent, design type, control source, genotyping procedure, genotype validation, age-matched status, study sample size, quality score and controls’ mean age were conducted, respectively. Total 17 unduplicated studies (patients/controls: 7561/8101) were assessable for PCa risk, and 4 unduplicated studies (1189 subjects) for peripheral blood IL-10 variation. Pooling all assessable studies identified a marginally significant association between the -1082A allele and increased PCa risk (odds ratio (OR)=1.10, 95% confidence interval [CI]: 1.00 to 1.21) (Heterogeneity I2=64.3%), and no significance was detected in sub-grouped analyses of this polymorphism. Contrastingly, the -592C allele was significantly associated with reduced PCa risk in both prospective (OR=0.85, 95% CI: 0.77 to 0.95) and population-based (OR=0.92, 95% CI: 0.84 to 1.00) studies (Heterogeneity I2=0.0% and 18.1%). Moreover, carriers of combined -592CA/CC genotypes had a significant higher level of peripheral blood IL-10 than the -592AA genotype carriers (weighted mean difference=0.45 and 0.54 mg/dL, 95% CI: 0.23 to 0.67 and 0.30 to 0.39). The above comparisons possessed a low probability of publication bias. In sum, our findings suggested that IL-10 gene -592A>C polymorphism may represent a promising candidate locus for the occurrence of PCa, and further signified a contributing role of this polymorphism in prostate carcinogenesis.
Highlights
Prostate cancer (PCa) is frequently occurring among men, and its mortality is continuing to rise, especially in some Western countries [1, 2]
The most important observation was that the mutation of -592A>C polymorphism was significantly associated with reduced prostate cancer (PCa) risk and increased peripheral blood IL-10 level
As the -592A>C polymorphism is in IL-10 gene promoter region, it appears reasonable to postulate that this polymorphism may alter an individual's susceptibility to PCa risk by regulating peripheral blood IL-10 level
Summary
Prostate cancer (PCa) is frequently occurring among men, and its mortality is continuing to rise, especially in some Western countries [1, 2]. It is of crucial importance to pinpoint genetic determinants that can explain the interindividual differences in susceptibility to PCa. Given the promising candidacy of IL-10 in prostate carcinogenesis, a large number of investigators were inspired to hunt for IL-10 genetic alternations strongly associated with PCa susceptibility, while their results remained indeterminate [13,14,15,16,17]. Given the promising candidacy of IL-10 in prostate carcinogenesis, a large number of investigators were inspired to hunt for IL-10 genetic alternations strongly associated with PCa susceptibility, while their results remained indeterminate [13,14,15,16,17] This may attribute to between-study distinctions in respect of ethnicity, design type, sample collection, statistical power and so forth. A special consideration was given to probe into various origins of between-study heterogeneity
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
