The Impact of IL-6 serum level on Tonsillitis and Tonsillectomy Patients infected with Streptococcus pyogenes

Abstract

Acute tonsillitis is a primary medical care consultation that may develop to recurrent tonsillitis (RAT), chronic tonsillitis and ~30% of patients require a tonsillectomy, which is associated with a high frequency of missed work or influence on quality of life The present study included 100 patients attending to Al-Saddar Medical city in ENT unit in Najaf governorate. The Patients were classified into two groups: seventy patients with tonsillitis who were subdivided into (36) as acute tonsillitis, (23) patients with chronic tonsillitis and (11) with recurrent tonsillitis as well as thirty patients with tonsillectomy. Swabs were taken from tonsil surface and from tonsil core then culturing on different media for 24 hours at 37 °C for bacterial growth and diagnosis by morphological, biochemical and Vitek 2 system, two ml of a venous blood sample was collected from each patient and control for ELISA testing to determine the level of IL-6. This study has shown that higher frequency of tonsillitis in males. The highest percentage of patients appeared with Grade 3 (33.6%), followed by Grade 2 (22.7%), in tonsillitis patients and Hrade 4, grade 3 in tonsillectomy patients. Also the age group of 1-10 years more frequency 34.4%. Culture investigation shows 16 (16%) swabs gave negative bacterial growth and 84 (84%) swabs gave positive bacterial growth from which about 108 isolates as poly and monobacterial growth (data not show). the 108 isolates appear that G+ ve bacteria recorded 88 (81.5%) with more frequency to S.pyogenes 35 (32.4%) isolates. The level of IL-6 highly increase in serum of tonsillitis and tonsillectomy patients compared with healthy controls. IL-6 serum level was highly increased among the patients in grade 3, 4 and highly significant increase in recurrent and chronic patients. As a result S.pyogenes is the most predominant bacterial agents in surface and core tonsillitis. IL-6 play important role in healing inflammation of tonsils.