Abstract
Psoriasis, a chronic disease, is associated with a higher prevalence of comorbidities and has negative impact on health-related quality of life (HRQOL). The objective was to investigate the effect of comorbidities on HRQOL, and psoriasis severity measured appropriately by the dermatology life quality index (DLQI) and the psoriasis area severity index (PASI) before, and after a 3-month treatment and the median DLQI or PASI reduction from baseline in the adult psoriatic patients receiving various types of treatment. The study included 184 adult plaque psoriatic patients. DLQI and PASI scores were assessed in the studied patients before the therapy (a baseline visit) and after a 3-month treatment (a control visit) depending on the presence of comorbidities. Psoriatic patients with comorbidities had worse HRQOL and more severe skin lesions. The presence of comorbidities had a negative effect on the outcome of treatment with the use of conventional therapy. The outcome of therapy with biological agents was independent of each of the analyzed factors. Biological treatment had a high effectiveness on the psoriatic skin lesions improvement despite the presence of comorbidities, whereas methotrexate was effective even if the patients had co-existing hypertension. In psoriatic patients receiving systemic conventional treatment but not biological treatment, comorbidities had a negative impact on HRQOL and psoriasis severity.
Highlights
Impact of Hypertension, Diabetes, Lipid Disorders, Overweight/Obesity and Nicotine Dependence on Health-Related Quality of Life and Psoriasis Severity in Psoriatic Patients
The aim of the study was to investigate the impact of comorbidities, overweight/obesity and nicotine dependence on health-related quality of life (HRQOL) measured by the dermatology life quality index (DLQI) prior to and after a 3-month treatment
Diabetes, lipid disorders as well as overweight/obesity and nicotine dependence are more prevalent in psoriatic patients than in the general population, they were selected as representative comorbidities to investigate their impact on health-related quality of life (HRQOL) and psoriasis severity in psoriatic patients receiving systemic conventional treatment with methotrexate, cyclosporine, retinoids and biological treatment
Summary
Impact of Hypertension, Diabetes, Lipid Disorders, Overweight/Obesity and Nicotine Dependence on Health-Related Quality of Life and Psoriasis Severity in Psoriatic Patients. Biological treatment had a high effectiveness on the psoriatic skin lesions improvement despite the presence of comorbidities, whereas methotrexate was effective even if the patients had co-existing hypertension. In psoriatic patients receiving systemic conventional treatment but not biological treatment, comorbidities had a negative impact on HRQOL and psoriasis severity. The health-related quality of life (HRQOL) in psoriatic patients is most often measured and assessed with the use of the dermatology life quality index (DLQI) which consists of 10 questions concerning the patient’s daily routines, social and professional activities as well as their feelings and experiences [5,6]. The psoriasis area and severity index score is a measurement of the erythema, thickness, scaling published maps and institutional affiliations
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