The impact of high intensity interval training on serum chemerin, tumor necrosis factor-alpha and insulin resistance in overweight women

Abstract

BackgroundChemerin is an adipokine that may mediate the link between obesity, inflammation, insulin resistance, and cardiovascular disease. The aim of present study was to elucidate the impact of high-intensity interval training on serum levels of chemerin, tumor necrosis factor-alpha (TNF-α) and insulin resistance in overweight women. MethodsTwenty-eight overweight, health and young women (mean age; 30.03 ± 3.13 years, mean Body Mass Index; 27.99 ± 2.91 kg/m2, mean body fat percent; 36.07 ± 1.48%) were randomly assigned to either the control group (CG) or high intensity interval training group (HIIT). The participants exercised for three days per week for 8 weeks. Fasting blood samples were drawn before and after the exercise training program. ResultsThe results indicated a significant reduction in serum chemerin and TNF-α concentration in HIIT group than CG. In addition, lipid profile improved following HIIT. Furthermore, weight, body mass index, body-fat percent and waist-to-hip ratio significantly reduced following HIIT. However, the results revealed no significant differences in insulin resistance and insulin levels between HIIT and CG group. ConclusionsIt's appeared that TNF-α and chemerin attenuations by intensive interval training are associated with improvements in body composition in overweight women. Therefore, performing this type of exercise is suggested for weight management and preventing from overweight and obesity complications.