The Impact of Hesperidin on Cognitive Deficit and Neurobehavioural Disorders: A Systematic Review and Meta-Analysis of Preclinical Individual Studies

Abstract

Purpose of Review Experimental evidence suggests that flavonoids prevent neurodegeneration and improves cognitive function. In this study, we systematically reviewed the effect of hesperidin on cognitive deficits and neurobehavioural outcomes in in vivo studies.Recent Findings: A systematic search of PubMed, EBSCOhost, Web of Science, Scopus and ProQuest was conducted. Meta-analysis was performed on the effect of hesperidin on cognitive and neurobehavioural parameters (Morris Water Maze, Y-Maze, elevated plus maze, rotarod test, locomotion activity, passive avoidance test, open field test and forced swimming test). The mixed effect model was used to compute the standard mean difference (SMD). A total of 1069 documents were retrieved. However, 46 studies were included in the systematic review and meta-analysis. Our findings revealed that hesperidin did not significantly affect cognitive performance in normal rats compared with placebo. Moreover, hesperidin improved memory and learning, sensorimotor function and locomotion activity in cognitive impaired rats. Hesperidin did not show any significant effect on anxiety-related outcomes in the diseased model.Summary: Hesperidin improved cognitive function and neurocognitive effects could be associated with its neuroprotective effects against neuroinflammation, oxidative stress-induced neuronal damage, inhibition of cholinergic deficit and mitochondrial dysfunction. These results correlate with available scientific evidence on the effect of hesperidin on cognitive dysfunction and neurobehavioural deficits in cognitive-impaired rats.