Abstract
Introduction. Oxygen, reacting with organic compounds in living organisms, oxidizes them without being completely reduced due to numerous exogenous as well as endogenous factors. As a consequence, free radicals or reactive oxygen species are formed. Health resort-based balneophysiotherapy is a comprehensive therapeutic intervention that triggers positive therapeutic effects within the entire system. Material and Methods. The objective of the study was to assess the impact of health resort-based balneophysiotherapy on the levels of nonenzymatic endogenous antioxidants in patients with degenerative motor organ diseases, as well as to determine potential correlation of these changes with free radical-mediated processes. Observation was carried out in patients undergoing health resort therapy as part of 21-day stay periods. The study population consisted of n = 110 patients with articular and spinal pains due to degenerative diseases or discopathies. Results Reduced bilirubin and albumin levels as well as increased uric acid levels were observed in the study group following the health resort treatment. Conclusions Bilirubin and albumin levels were reduced while uric acid levels were increased as the result of health resort therapy in patients with degenerative motor organ diseases. The observed changes in the levels of nonenzymatic endogenous antioxidants depend on free radical-mediated systemic transformations. The trial is registered with NCT03405350.
Highlights
Oxygen, reacting with organic compounds in living organisms, oxidizes them without being completely reduced due to numerous exogenous as well as endogenous factors
Changes in the plasma levels of albumin, bilirubin, and uric acid were observed in the study, including a drop in the levels of albumin and bilirubin and an increase in the levels of uric acid
Uric acid is an important member of the class of low-molecular antioxidants
Summary
Oxygen, reacting with organic compounds in living organisms, oxidizes them without being completely reduced due to numerous exogenous as well as endogenous factors. The objective of the study was to assess the impact of health resort-based balneophysiotherapy on the levels of nonenzymatic endogenous antioxidants in patients with degenerative motor organ diseases, as well as to determine potential correlation of these changes with free radical-mediated processes. Bilirubin and albumin levels were reduced while uric acid levels were increased as the result of health resort therapy in patients with degenerative motor organ diseases. Reactive oxygen species include singlet opxeryogxeinde(1(OH22)O, 2s)u, panerdoxhiydderoaxnidioenrardaidciacla(l⋅O(OH2)⋅.−)I,n hydrogen a healthy system, the levels of free radicals are strictly controlled by the maintenance of equilibrium between formation and elimination of reactive oxygen species. Disturbance in this equilibrium is referred to as oxidative stress.
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