Abstract
Introduction: Various studies have shown the benefi cial effects of green tea, not only on cardiovascular diseases but also on type 2 diabetes.Methods: In this study, the preparation of green tea water extract has been standardized to (-)-epigalocatechin gallate (EGCG), the major component of green tea. The role of green tea water extract on blood fl uidity and diabetes diseases has been studied in 13 Fructose-Fed Rat (FFR). The rats were given high fructose diet ad libitum for one week and then combination with green tea water extract every day for 6 days.Results: The results show, green tea water extract can reduces 100 μL blood passage times of wistar rat signifi cantly (p<0.01) by Micro-Channel Array Flow Analyzer (MC-FAN) instrument. Green tea water extract also had strong effect in reducing abdominal fat (p<0.05), blood glucose level (p<0.01) and body weight (p<0.01).Conclusion: These results suggest that green tea water extract may has benefi cial effects for the treatment of diabetes and reduce blood viscosity.
Highlights
Various studies have shown the beneficial effects of green tea, on cardiovascular diseases and on type 2 diabetes
In the chromatograms of the epigalocatechin gallate (EGCG) standard solution analyzed by HPLC, the peak of standard EGCG was identified as the single peak and separated completely from other compound in sample of green tea extract
Concentration of EGCG in sample extract green tea was found 4.53 + 0.03 % and calculated from dry weight. This standardized sample was used for further examination in blood fluidity and diabetic impact of fructose fed rat
Summary
Various studies have shown the beneficial effects of green tea, on cardiovascular diseases and on type 2 diabetes. The role of green tea water extract on blood fluidity and diabetes diseases has been studied in 13 Fructose-Fed Rat (FFR). Green tea water extract had strong effect in reducing abdominal fat (p
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