Abstract
SignificanceGlucose metabolism has been proven as an essential process for proliferating keratinocytes, which highlights the importance of glucose transporter-1 (GLUT1) not only in the onset of psoriasis but also in the progression and severity of this inflammation-driven disease. Recent evidence showed that overexpressed GLUT1 transporter may be a potential target for the treatment of psoriasis and other hyperproliferative skin diseases. ApproachFor this reason, we attempted to synthesize and evaluate the photocytotoxic activity and intracellular uptake of glucose-conjugated zinc phthalocyanine (Glu-ZnPc), in order to prove its preferential accumulation in highly proliferative psoriatic keratinocytes. HaCaT cells stimulated with exogenous cytokines (TNF-α, IL-6, IL-17, IL-23, IL-36) were used as in vitro model. ResultsWe managed to synthesize Glu-ZnPc that is stable, water soluble, cytotoxic, and has a more efficient transport system than unconjugated ZnPc. ConclusionsWe believe that GLUT1 overexpression could potentially be utilized by using selective glucose- conjugated photosensitizers against psoriasis.
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