Abstract
PurposeAlthough case–control studies have evaluated the role of variant inflammatory-related loci in prostate cancer, their impact is virtually unknown among men of African descent. To address this, we evaluated the impact of inflammatory cytokine single nucleotide polymorphisms (SNPs) on prostate cancer risk for men of African descent.MethodsForty-four SNPs in inflammatory cytokine-associated genes were evaluated among 814 African-American and Jamaican men (279 prostate cancer cases and 535 controls) using Illumina’s Golden gate genotyping system. Individual SNP effects were evaluated using logistic regression analysis.ResultsFour SNPs were modestly associated with prostate cancer after adjusting for age. In the total population, inheritance of the IL1R2 rs11886877 AA, IL8RB rs11574752 AA, TNF rs1800629 GA + AA, and TNF rs673 GA genotypes modestly increased prostate cancer risk by 1.45 to 11.7-fold relative to the referent genotype. Among U.S. men, age-adjusted dominant, recessive and additive genetic models for the IL1R2 rs11886877 locus were linked to an increase in prostate cancer susceptibility. However, these main effects did not persist after adjusting for multiple hypothesis testing.ConclusionOur preliminary data does not strongly support the hypothesis that inflammatory-related sequence variants influence prostate cancer risk among men of African descent. However, further evaluation is needed to assess whether other variant inflammatory-related genes may contribute to prostate cancer risk and disease progression in larger and ethnically diverse multi-center studies.
Highlights
Chronic inflammation is thought to predispose an individual to cancer development [1]
For age-adjusted risk models, elevations in prostate cancer susceptibility were observed among carriers of IL1R2 rs1188687 7AA (OR = 1.92; 95%confidence intervals (CIs) = 1.11, 3.32), IL8RB rs11574752 GA + AA (OR = 38.40; 95%CI = 3.86, 382.8), tumor necrosis factor (TNF) rs1800629 GA + AA (OR = 1.53; 95%CI = 1.06, 2.20), and TNF rs673 GA (OR = 1.50; 95%CI = 1.04, 2.16) genotypes with risk estimates ranging from 1.50-38.4
Chronic inflammation is an established risk factor of prostate cancer and many studies argue that it can lead to prostate cancer development
Summary
Chronic inflammation is thought to predispose an individual to cancer development [1]. This relationship is supported by a number of studies involving inflammatory bowel disease, colon cancer, hepatitis, liver cancer, pancreatitis, and pancreatic cancer [2,3,4,5,6]. While men of African Descent suffer disproportionately from this disease [2,3,14,15], there is limited information about the positive link between variant cytokine genes and prostate cancer development in this population [16,17].
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