Abstract

<b>Background/Aim:</b> The best lung function achieved post-lung transplant (LTx) is associated with survival. The impact of donor-recipient sex match on best lung function post-LTx is not well studied. <b>Methods:</b> Consecutive double LTx recipients were prospectively enrolled for oscillometry and standard pulmonary function tests (cPFT) from 2017 onwards. Baseline values of 224 patients with a minimum 6 months of follow-up were compared among the 4 donor-recipient sex match groups. Stepwise regression was conducted to assess predictor modeling ability, given sex match. <b>Results:</b> The baseline % predicted cPFT metrics were similar amongst the 4 groups. In contrast, the baseline oscillometry metrics of total lung resistance (R5), ventilatory homogeneity and elastance (AX and X5) were significantly better (p &lt; 0.001) in the donor male/recipient male group. Preliminary analysis to evaluate the additive or interactive effects between baseline parameters and sex match groups indicated that sex match moderates the effect of at least one predictor in modeling all outcomes except CLAD (Figure). <b>Conclusion:</b> Donor-recipient sex match was associated with differences in respiratory mechanics after LTx with best values in the male/male matched group. Further multivariate analyses will be conducted to determine the nature of the effect on baseline cPFT and oscillometry metrics after correcting for confounding variables.

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