Abstract
Temporal Lobe Epilepsy (TLE) is the most common epileptic syndrome in adult, with a high documented drug resistance rate. There are many forms of presentation of TLE, that varies significantly in severity and seizure control. Many studies have shown brain atrophy in patients with temporal lobe epilepsy, but few have compared the impact of refractory seizures on grey and white matter atrophy. In this study we applied voxel-based morphometry (VBM), a MRI morphometric technique largely used in epilepsy and others neurological disorders, to evaluate the relation between severity of the disease and brain atrophy in TLE patients.
Highlights
It is estimated that approximately 1/3 of patients with epilepsy are resistant to Anti-Epileptic Drugs (AEDs) and, in this context, Temporal Lobe Epilepsy (TLE) represents the primary source of refractory epilepsy, with the highest rate of drug-resistant patients2
We evaluated the patterns of white (WM) and grey matter (GM) atrophy in patients with TLE with refractory, fluctuating, early and late seizures control
We observed areas of white and grey matter atrophy in the brains of patients affected by TLE in relation to healthy controls
Summary
Temporal Lobe Epilepsy (TLE), a subtype of focal type epilepsy, is the most common epileptic syndrome in adults, affecting around 1% of the world population. It is estimated that approximately 1/3 of patients with epilepsy are resistant to Anti-Epileptic Drugs (AEDs) and, in this context, TLE represents the primary source of refractory epilepsy, with the highest rate of drug-resistant patients. Little has been studied about the impact of seizure control on the observed abnormalities. We evaluated the patterns of white (WM) and grey matter (GM) atrophy in patients with TLE with refractory, fluctuating, early and late seizures control. Patients with early (Group 3) and late (Group 4) seizures control. From the results shown, patients with early control of seizures appear to have more exuberant areas of atrophy than the group of patients with late seizure control. There was a widespread pattern of WM atrophy, mainly in the refractory group
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