Abstract
Background/aim Diminished ovarian reserve (DOR) represents a major challenge in reproductive medicine, as it is often associated with poor ovarian stimulation response, high cycle cancellation rate, and low pregnancy rate. The aim of the present study is to compare the clinical pregnancy rates in intracytoplasmic sperm injection-embryo transfer (ICSI-ET) cycles in patients with different DOR etiologies. Materials and methods Patient data were recorded with a computer-based program called Success Estimation Using a Ranking Algorithm (SERA). Overall, 459 patients were divided into 3 groups according to their DOR etiologies (Group A: idiopathic, n = 81; Group B: age-related, n = 294; Group C: previous ovarian surgery, n = 84). ResultsOut of 459 stimulation cycles, 378 (82.4%) reached the oocyte retrieval stage, while 201 (43.8%) had embryo transfers. There was no significant difference between the patients with different DOR etiologies in terms of embryo transfer and cycle cancellation rate. The patients who had embryo transfer were 44 (52.4%) in Group A, 38 (46.9%) in Group B, and 119 (40.5%) in Group C. There were no significant differences between the three groups (P = 0.114). The percentages of women who had oocyte retrieval were 84.5% in Group A, 70% in Group B, and 80.3% in Group C (P = 0.104). While clinical pregnancy per transfer was 35.8% in Group A, 19.8% in Group B, and 29.5% in Group C, there was no statistically significant difference between the groups (P = 0.113).ConclusionAlthough ovulation induction and ICSI-ET outcomes, including clinical pregnancy and live birth rates, were not significantly different with regards to the etiology of DOR, young women with DOR may benefit from assisted reproductive techniques.
Highlights
Diminished ovarian reserve (DOR) represents a major challenge in reproductive medicine
There was no significant difference between the patients with different DOR etiologies in terms of embryo transfer and cycle cancellation rate
Conclusion: ovulation induction and intracytoplasmic sperm injection-embryo transfer (ICSI-Embryo transfer (ET)) outcomes, including clinical pregnancy and live birth rates, were not significantly different with regards to the etiology of DOR, young women with DOR may benefit from assisted reproductive techniques
Summary
Diminished ovarian reserve (DOR) represents a major challenge in reproductive medicine. DOR is characterized by poor fertility outcomes and is often associated with a poor ovarian stimulation response, a high cancellation rate of in vitro fertilization embryo transfer (IVF-ET) cycles, and a significant decline in pregnancy rates even when assisted reproductive techniques are used [1]. Poor ovarian response (POR) to ovarian stimulation is a condition that seems to be common among women with DOR. To standardize the definition of POR, Ferraretti et al [2] proposed new criteria, known as the Bologna criteria, the Bologna criteria were found to be useful in predicting the outcome of IVF and for counseling purposes, their use in clinical trials has been questioned because they entail the risk of grouping together women with a large spectrum of various pathologies.
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