The Impact of COVID-19 Infection on Oxygen Homeostasis: A Molecular Perspective

Abdu I Alayash

doi:10.3389/fphys.2021.711976

Abstract

The novel coronavirus (2019-nCoV/SARS-CoV-2) causes respiratory symptoms including a substantial pulmonary dysfunction with worsening arterial hypoxemia (low blood oxygenation), eventually leading to acute respiratory distress syndrome (ARDS). The impact of the viral infection on blood oxygenation and other elements of oxygen homeostasis, such as oxygen sensing and respiratory mitochondrial mechanisms, are not well understood. As a step toward understanding these mechanisms in the context of COVID-19, recent experiments revealed contradictory data on the impact of COVID-19 infection on red blood cells (RBCs) oxygenation parameters. However, structural protein damage and membrane lipid remodeling in RBCs from COVID-19 patients that may impact RBC function have been reported. Moreover, COVID-19 infection could potentially disrupt one, if not all, of the other major pathways of homeostasis. Understanding the nature of the crosstalk among normal homeostatic pathways; oxygen carrying, oxygen sensing (i.e., hypoxia inducible factor, HIF) proteins, and the mitochondrial respiratory machinery may provide a target for therapeutic interventions.

Highlights

Division of Blood and Devices (DBCD), United States Food and Drug Administration, Silver Spring, MD, United States
Understanding the nature of the crosstalk among normal homeostatic pathways; oxygen carrying, oxygen sensing proteins, and the mitochondrial respiratory machinery may provide a target for therapeutic interventions
Under normal physiological settings the maintenance of cellular levels of oxygen is critical because either insufficient or excess oxygen leads to increased levels of reactive oxygen species (ROS), and both the delivery and the consumption of oxygen are precisely regulated by many different molecular mechanisms as part of overall oxygen homeostasis

Summary

Introduction

Division of Blood and Devices (DBCD), United States Food and Drug Administration, Silver Spring, MD, United States. As a step toward understanding these mechanisms in the context of COVID-19, recent experiments revealed contradictory data on the impact of COVID-19 infection on red blood cells (RBCs) oxygenation parameters. Understanding the nature of the crosstalk among normal homeostatic pathways; oxygen carrying, oxygen sensing (i.e., hypoxia inducible factor, HIF) proteins, and the mitochondrial respiratory machinery may provide a target for therapeutic interventions.

Results

Conclusion