Abstract
Methods Following navigator coronary MRA scout images, the LAD lumen was imaged in short axis before and during the cold pressor test (CPT) in normal controls and subjects with one or more atherosclerotic risk factors using either supine breath-hold double inversion T2 weighted spin echo imaging (38 subjects, 1.5 T Siemens Sonata) or prone breath-hold SSFP retrospectively gated cine imaging with a 4 element phased array carotid coil (39 subjects, 1.5 T Siemens Avanto). The % change in LAD lumen area with CPT was calculated. CT calcium scores were available or obtained by protocol in each subject and those undergoing prone imaging also had coronary CT angiography to exclude coronary stenoses. Linear associations between continuous variables were measured by Pearson and Spearman (non-parametric) correlation coefficients. ROC analysis was also performed. A p-value < 0.05 was deemed statistically significant.
Highlights
Coronary endothelial function (CEF) is a prognostic marker that worsens with progression of coronary atherosclerosis
We developed CMR methods for assessment of left anterior descending coronary artery (LAD) endothelial function (CEF) and examined its relationship to plaque burden and atherosclerotic risk factors
Following navigator coronary MRA scout images, the LAD lumen was imaged in short axis before and during the cold pressor test (CPT) in normal controls and subjects with one or more atherosclerotic risk factors using either supine breath-hold double inversion T2 weighted spin echo imaging (38 subjects, 1.5 T Siemens Sonata) or prone breath-hold SSFP retrospectively gated cine imaging with a 4 element phased array carotid coil (39 subjects, 1.5 T Siemens Avanto)
Summary
Address: 1St. Francis Hospital, Roslyn, NY, USA and 2St. Francis Hospital, Division of Cardiology, SUNY Stony Brook, Roslyn, NY, USA * Corresponding author from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P43 doi:10.1186/1532-429X-12-S1-P43. Abstracts of the 13th Annual SCMR Scientific Sessions - 2010 Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-info
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