Abstract
AbstractAbstract 4940 IntroductionMyelodysplastic syndrome (MDS) is a heterogeneous clonal hematopoietic cell disorder. The prognostic implication of comorbidities at diagnosis of MDS is emerging. ObjectiveWe aimed to investigate the impact of comorbidity on the patients with MDS. MethodTotally 263 MDS patients during a 15-year period in single institute were collected.The clinical characteristics and the extra-hematological systemic diseases at diagnosis were all registered in this database. Well established prognostic models, including original International Prognostic Scoring System (IPSS), WHO classification-based Prognostic Scoring System (WPSS), and total MDACC scores were evaluated in our cohort. ResultsComorbidity was present in 76. 4% of patients. In univariate and multivariate analysis, HCT-CI ≥ 3 was significantly associated with poor outcome. IPSS, WPSS and MDACC were informative to discriminate between risk groups of patients with MDS. By comparing AIC values in the Cox proportional hazards analysis, MDACC had superior prognostic value followed by IPSS and WPSS. A modified score incorporating HCT-CI and MDACC divided patients into four risk groups. The 3 year-survival rate was 72%, 40%, 31%, 4%, respectively. ConclusionBuilding new models incorporating comorbidities to current prognostic score help to predict survival in patients with MDS.Table:Patients baseline characteristics and comorbiditiesPatient No.%Age, years¡Ø 656524.7¡Ö 6519875.3GenderMale19875.3Female6524.7Comorbidity systemArrhythmia249.1Cardiac6524.7Inflammatory bowel disease00Diabetes7227.4Cerebrovascular disease155.7Psychiatric disturbance72.7Hepatic4517.1Obesity00Infection4717.9Rheumatologic134.9Peptic ulcer3111.8Renal124.6Pulmonary3312.5Prior solid tumor3513.3Heart valve disease93.4 [Display omitted] Disclosures:No relevant conflicts of interest to declare.
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