Abstract
Introduction Chronic sinusitis is considered one of the most important causes of olfactory dysfunction, and this is attributed to the obstructive effect of swollen mucosa and nasal polyps or inflammatory process in the olfactory mucosa. Patients and methods This study enrolled 60 patients [20 chronic rhinosinusitis with nasal polyps (CRSwp), chronic rhinosinusitis without nasal polyps (20 CRSsp), and 20 control] and used nestin antibody, a marker found in olfactory mucosa and directly related to function, to prove the etiology of olfactory dysfunction in CRS. Results It was found that nestin staining is decreased in both cases groups, but on the contrary, patients with CRSwp have more olfactory dysfunction than patients with CRSsp. This means that the inflammatory process is strongly present in both case groups; however, the presence of polyps increases olfactory function loss. Conclusion This study led to an important conclusion that both obstructive and inflammatory causes contribute to olfactory dysfunction in patients with CRS.
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