Abstract
fromcirculatorydiseaseandseveralcancers in subjects with active HCV infection. The mortality rates of subjects who were only HCV antibody positive were similar to the rates of those without markers of HCV. This is one of several studies in which the effect of chronic HCV infection on overall and specific causes of mortality was examined. However, in this study recruiting a cohort from the community minimized selection bias. In addition, subjects with hepatitis B virus (HBV) or HIV coinfections were excluded in order to estimate the specific effect of chronic HCV on mortality. The strong causative effect of chronic HCV infection on mortality from chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC) has been observed in several investigations since the virus was identified [2–11]. Liver diseases have contributed substantially to the overall increased mortality in patients with chronic HCV infections. However, the increased mortality among persons with chronic HCV infections also may be related to several underlying
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