The impact of Chitosan Lecithin on the mild cognitive impairment patients' semantic understanding by event-related potential N400

Abstract

Objective To study the impact of Chitosan Lecithin on the mild cognitive impairment(MCI) patients′ semantic understanding by event-related potential N400. Methods 32 patients with MCI were screened from 500 elder people aged Court in Weifang by mini-mental state examination(MMSE) scale, and were divided into two groups: the observation group (n=16) and the control group (n=16) by the table of random numbers.The observation group were given Chitosan Lecithin while the control group were given an equal dose of placebo.The intervention time was 2 months.The subjects were asked to conduct semantic judgement by semantic violation experiment.Thirty-two channels electroencephalogram(EEG)was recorded by Neuroacan Nuamps Systerm and analyzed data. Results 1) Specific component N400 was found in both groups, which was distributed at the frontal, central and parietal regions.2) The observation group reaction time and correct rate were respectively (965.13±178.07)ms and (92.56±2.36)% , while the control group were respectively (1126.13±252.77)ms and (85.28±5.73)%, with significant difference(P<0.05 ).3) Compared with N400 in control group, N400 latency was shorter ( (425.28±47.26) ms vs (456.19±37.75)ms, F=6.01, P<0.05) and amplitude was higher((4.79±2.18)μV vs (3.59±1.33)μV, F=5.96, P<0.05). Conclusion Chitosan lecithin has the effect of N400 latency and amplitude, it may be helpful for the patients of MCI in semantic understanding. Key words: Chitosan Lecithin; Mild cognitive impairment; Event-related potentials(ERP); N400