Abstract
A number of conditions have a higher prevalence among people who are obese or old, and this includes chronic pain. These two demographics are increasing, with obesity nearly tripling since 1975 and the number and fraction of older people are increasing faster than ever before. These changes lead to alterations of the lipid composition of cell membranes. When the lipid composition changes it influences the biophysical properties of the membrane and is thought to be affecting the dynamics of membrane proteins. The cannabinoid receptor 1 (CB1) is a pain receptor which is found in high abundance in neuronal and plasma membranes. The CB1 is an interesting target to investigate when it comes to chronic pain as it is a non-opioid target. We found that the composition of the local lipid environment influences the protein dynamics. The global biophysical properties indirectly play a role by modulating the local lipid environment around the protein.
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