Abstract
The article describes a laboratory study of nematocidal properties of flavourings with antibacterial effect against Ascaris suum (Goeze, 1782) and Trichuris suis Schrank, 1788. In the experiments, eight concentrations of food additives with antibacterial properties were used: cinnamaldehyde, benzoic acid, formic acid, linalool, citral, β-ionone. Minimum LC50 value for eggs of A. suum was observed while using cinnamaldehyde and benzoic acid – 1.62 ± 0.37% and 1.69 ± 0.14%, and for eggs of T. suis – 0.57 ± 0.03% and 1.80 ± 0.11% respectively. The lowest influence on the development of eggs of nematodes of pigs’ A. suum and T. suis was exerted by formic acid, linalool, citral and β-ionone. In eggs of A. suum and T. suis, larvae formed in 21 and 50 days even during exposure to 3% emulsions of these substances. The strongest negative impact on the eggs of parasitic nematodes was displayed by cinnamaldehyde flavouring. Further study on nematocidal properties of flavourings, as well as their mixtures, would contribute to the development of preparations which would have a strong effect on eggs and larvae of nematodes of animals and humans.
Highlights
Two of the commonest helminthiases of swine around the globe are ascariasis and trichuriasis
Ren et al (2020) determined the potential of formic acid and monolaurin as an alternative to antibiotics in the diet of piglets infected by ETEC: combination of formic acid and monolaurin in the diet of piglets infected by ETEC can become an alternative to antibiotics for reduction of the inflammatory process
We studied antiparasitic properties of these substances against nematode larvae L1–3 Strongyloides papillosus (Wedl, 1856) and L3 Haemonchus contortus (Rudolphi, 1803) (Boyko & Brygadyrenko, 2019a, 2019b): notable nematocidal activity was displayed by cinnamaldehyde, benzoic acid and formic acid towards larvae of S. papillosus and H. contortus
Summary
Two of the commonest helminthiases of swine around the globe are ascariasis and trichuriasis. The pathogens of these parasitic diseases cause economic damage to pig farming (Lindgren et al, 2019; Nwafor et al, 2019; Zheng et al, 2020). Most farmers use synthetic broad-spectrum anthelmintic preparations against ascariasis and trichuriasis of pigs, though some of them have notable side effects (Jakobsen et al, 2019; Vandekerckhove et al, 2019). Oh et al (2016) evaluated the effect of several disinfecting preparations on embryogenic development of eggs of A. suum. According to the results of their experiment, 3.0% cresol and 0.02% sodium hypochlorite can slow the development, but not inactivate the eggs of A. suum. Likewise povidone-iodine in 10% solution killed no eggs even during 60 min exposure
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