Abstract
Background and Purpose: The relationship between cerebral microbleeds (CMBs) and prognosis in patients with ischemic stroke is still unclear. Our aim here was to verify the relationship between CMBs and functional outcomes in patients with minor ischemic stroke treated with antiplatelet therapy.Methods: We retrospectively reviewed consecutive patients with a non-cardiogenic minor ischemic stroke (NIHSS <4 on admission) who underwent initial brain magnetic resonance imaging within the first 48 h following symptom onset. The patients were divided into two groups based on the presence or absence of CMBs and the two groups were adjusted using the pre-stroke modified Rankin scale (mRS). Poor outcome was defined as an mRS score in the 3–6 range measured 90 days after symptom onset. Logistic regression analyses were performed to determine the factors independently associated with poor outcome.Results: A total of 240 patients (187 men, median age 66 years old) were enrolled in our study. There was a non-significant trend toward a worsening shift of 3-month mRS score distribution in the CMB group compared with the no-CMB group. Multivariate analysis revealed that the presence of CMBs was independently predictive of poor outcome (OR, 3.44; 95% CI, 1.08–10.93; P = 0.036).Conclusion: Our findings suggest that the presence of CMBs is the predicting factor of poor outcome in minor ischemic stroke patients.
Highlights
Cerebral microbleeds (CMBs) are considered biomarkers of cerebrovascular disease, and of small vessel disease [1, 2]
Patients were eligible for this study if the admission occurred within 48 h after symptom onset and if they received a diagnosis of non-cardiogenic minor stroke according to the TOAST classification [10], with baseline National Institutes of Health Stroke Scale (NIHSS)
Of the 689 consecutive patients admitted during the study period with an ischemic stroke, 266 were enrolled in our study (Figure 1)
Summary
Cerebral microbleeds (CMBs) are considered biomarkers of cerebrovascular disease, and of small vessel disease [1, 2]. Stroke patients with CMBs have higher recurrence rates for both ischemic and hemorrhagic strokes [3,4,5], and have increased mortality rates [6,7,8] compared with stroke patients without CMBs. the association between CMBs and stroke recurrence and/or mortality is well-established, little is known about the functional outcomes of. The Impact of Cerebral Microbleeds Presence on Outcome stroke patients with CMBs. The aim of the present study was to investigate whether CMBs affect the functional outcome of patients presenting with minor ischemic stroke. The relationship between cerebral microbleeds (CMBs) and prognosis in patients with ischemic stroke is still unclear. Our aim here was to verify the relationship between CMBs and functional outcomes in patients with minor ischemic stroke treated with antiplatelet therapy
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