THE IMPACT OF CARDIOVASCULAR AND BRONCHOPULMONARY DISEASES ON COENZYME Q10 PLASMA CONCENTRATION

V I Zozina,E S Melnikov,L M Krasnykh,O A Goroshko,V G Kukes

doi:10.47093/22187332.2019.1.16-21

Abstract

Introduction. Coenzyme Q10 plays an important role in the human body. Its main function is not only the transfer of electrons in the mitochondrial respiratory chain for the ATP synthesis, but it is also one of the most powerful antioxidants in the body.The aim of research is to monitor the relationship between cardiovascular and pulmonary diseases, and the concentration of coenzyme Q10 in the blood plasma.Materials and methods. Coenzyme Q10 was determined using high performance liquid chromatography with mass spectrometric detection.Results and discussion. During the study, it was found that the concentration of coenzyme Q10 in plasma is aﬀected not only by the main diseases, but also by comorbidities, as well as by the therapy. A sharp decrease in plasma coenzyme Q10 concentration was noted in patients with cardiovascular pathologies, especially in those with concomitant endocrine diseases. Also, it was recorded a decrease in the concentration of coenzyme Q10 in the plasma of patients with pneumonia. Conclusion. During the experiment, the coenzyme Q10 concentration was found to be dependent on cardiovascular and pulmonary diseases.

Highlights

Coenzyme Q10 plays an important role in the human body
it was found that the concentration of coenzyme Q10
A sharp decrease in plasma coenzyme Q10 concentration was noted in patients with cardiovascular pathologies

Summary

Introduction

Coenzyme Q10 plays an important role in the human body. Its main function is the transfer of electrons in the mitochondrial respiratory chain for the ATP synthesis, but it is one of the most powerful antioxidants in the body.СЕЧЕНОВСКИЙ ВЕСТНИК Т. 10, No 1, 2019 г. / SECHENOV MEDICAL JOURNAL V. 10, NO. 1, 2019The aim of research is to monitor the relationship between cardiovascular and pulmonary diseases, and the concentration of coenzyme Q10 in the blood plasma. Разработать и валидировать методику количественного определения CoQ в плазме крови при 10 помощи высокоэффективного жидкостного хроматографа (ВЭЖХ-МС/МС). Измерить концентрации CoQ в плазме крови в Возраст пациентов варьировал от 55 до 70 лет, когда средняя концентрация CoQ у здорового человека составляет

Results

Conclusion