Abstract
BackgroundTo explore the effects of cardiac exercise rehabilitation on peripheral blood endothelial progenitor cells (EPC) in elderly patients with chronic heart failure.Methods80 elderly patients with chronic heart failure were selected from March 2017 to March 2019 and randomly divided into two groups (N = 40). The control group was treated routinely and walked freely for 30–60 min every day. The patients in the exercise rehabilitation group developed a cardiac exercise rehabilitation plan. Then, cardiac function and peripheral blood B-natriuretic peptide (BNP) levels in the two groups were compared. The cell viability, proliferation, apoptosis, and invasion ability of EPCs were detected. The levels of the PI3K/AKT pathway and eNOS and VEGF were compared.ResultsThere were no significant differences in all indexes between the two groups before treatment (P > 0.05), and both improved significantly after treatment (P < 0.05). After treatment, LVEF and LVFS in the exercise rehabilitation group were significantly higher than those in the control group (P < 0.05), and LVEDD and LVESD were significantly lower than those in the control group (P < 0.05). The BNP level in the exercise rehabilitation group was significantly lower than that in the control group (P < 0.05). The cell viability, proliferation, invasion ability of EPC, and the levels of PI3K, AKT, eNOS, and VEGF mRNA and protein in the exercise rehabilitation group were significantly higher than those in the control group. Apoptosis rate was significantly lower than those in the control group (P < 0.05).ConclusionsVisceral exercise rehabilitation can improve cardiac ejection and myocardial function in elderly patients with chronic heart failure, and can promote the vitality, proliferation, and invasion of peripheral blood EPC, and promote the expression of eNOS and VEGF by upregulating the PI3K/AKT pathway to promote angiogenesis and endothelial function.
Highlights
To explore the effects of cardiac exercise rehabilitation on peripheral blood endothelial progenitor cells (EPC) in elderly patients with chronic heart failure
This study has mainly analyzed the therapeutic effects of cardiac exercise rehabilitation on elderly patients with chronic heart failure (CHF) and the influence of EPC function and PI3K/Akt pathway in peripheral blood. It preliminarily explored the therapeutic mechanisms of cardiac exercise rehabilitation and to see whether the outcome can contribute to the cardiac ejection capacity and myocardial functions in patients with CHF. Study design This is an interventional study that analyzed the therapeutic mechanisms of cardiac exercise rehabilitation on CHF patients
Intervention methods According to the guidelines published by Xuezhai et al, both the control group and exercise rehabilitation group in our study received conventional treatment based on the specific conditions of each patient [15]
Summary
To explore the effects of cardiac exercise rehabilitation on peripheral blood endothelial progenitor cells (EPC) in elderly patients with chronic heart failure. The incidence rate of heart failure (HF) is increasing year by year. The prevalence of chronic heart failure (CHF) is over 10% in the population over 70 years old [1]. The incidence rate of new CHF has dropped significantly in the past decades, the number of hospitalized patients, arrhythmia, and quality of life of patients has not improved significantly [2]. There are many limitations in the treatment of heart transplantation and left ventricular-related devices. A large number of clinical studies show that cardiac exercise rehabilitation can significantly improve the exercise tolerance of patients with HF and improve the cardiac function, quality of life, mortality, and prognosis of patients [3]
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