Abstract
Among military personnel participating in armed confl icts around the world, blast- induced traumatic brain injury is common. Mild blast- induced traumatic brain injury is characterized by clinical signs in the form of impaired cognitive functions, including memory. In this regard, the objective is to study the features of the infl uence of an blast-i nduced traumatic brain injury on conditioned refl ex activity in the experiment. The studies were carried out on 18 white male Wistar rats aged 5-7 months, weighing 180.0-220.0 g, which were kept under standard vivarium conditions of Dnipro State Medical University. Selected rats were divided into three groups: I group – experimental (n=6), whose animals were anesthetized with halothane (Halothan Hoechst AG, Germany), fi xed and simulated blast-i nduced traumatic brain injury by generating a baroacoustic wave with an excess pressure of 26.4±3.6 kPa on your own manufactured device. II group – sham (n=6), the animals of which were subjected only to inhalation anesthesia with halothane and fi xation in a horizontal position, and III group – intact (n=6). The passive avoidance response was reproduced according to the standard method in a light-dark chamber with an electrifi ed fl oor in a dark chamber. The latent period of entry into the dark chamber was determined in rats that had undergone preliminary training.As a result of the data analysis obtained during the experiment, it was found that a mild blast- induced traumatic brain injury leads to a violation of passive avoidance response on the 3rd day after the injury (lengthening of the latent time by 28-31%, p˃0.05), which progressed by 21 (100-79%, p˃0.05) and 28 (100-96%, p<0.05) days of the post-traumatic period. Taking into previous studies, the changes which we obtained are indicate signifi cant secondary damage by biologically active substances, which lead to the launch of neurodegenerative processes and, as a result, memory impairment.
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