The Impact of Aortic Angulation on Contemporary Transcatheter Aortic Valve Replacement Outcomes.

Abstract

The aim of this study was to investigate whether the degree of aortic angulation (AA) affects outcomes after transcatheter aortic valve replacement (TAVR) using newer-generation transcatheter heart valves (THVs). AA≥48° has been reported to adversely influence accurate THV deployment, procedural success, fluoroscopy time, and paravalvular leak (PVL) in patients undergoing TAVR with early generation self-expanding (SE) THVs. A retrospective observational study was conducted among 841 patients across all risk strata who underwent transfemoral TAVR using the balloon-expandable (BE) SAPIEN 3 or the SE CoreValve Evolut PRO from 2015 to 2020. The previously published cutoff of 48° was used to analyze procedural success and in-hospital outcomes according to THV type. Receiver-operating characteristic analysis was performed to investigate the impact of AA on an in-hospital composite outcome (need for >1 THV, more than mild PVL, new permanent pacemaker implantation, stroke, and death). AA≥48° did not influence outcomes in patients with BE THVs. Additionally, AA≥48° did not influence procedural success (99.1% vs. 99.1%; p=0.980), number of THVs used (1.02 vs. 1.04; p=0.484), rates of more than mild PVL (0.4% vs. 0%; p=0.486), new permanent pacemaker implantation (11.8% vs. 17.1%; p=0.178), in-hospital stroke (3.9% vs. 1.8%; p=0.298), or in-hospital death (0.4% vs. 0.9%; p=0.980) in patients with SE THVs. Receiver-operating characteristic analysis demonstrated similar outcomes irrespective of AA, with areas under the curve of 0.5525 for SE THVs and 0.5115 for BE THVs. AA no longer plays a role with new-generation BE or SE THVs in contemporary TAVR practice. AA≥48° did not affect procedural success or in-hospital outcomes and should no longer be a consideration when determining THV selection.