Abstract
Review Objective The objective of this systematic review is to systematically review the best available evidence to determine whether antipsychotic side effects have an impact on attitudes toward medication in patients with schizophrenia. More specifically, the review question is: What is the impact of antipsychotic side effects on attitudes toward medication in patients with schizophrenia? Criteria for Considering Studies for This Review Types of participants This review will consider studies that include adults who have a confirmed diagnosis of schizophrenia receiving medication treatment (typical or atypical antipsychotics) from any health care settings (inpatient or outpatient). Types of interventions This review will include studies that investigate the impact of antipsychotics side effects using standardised instruments (both self-rated and clinician-rated instruments), such as the Liverpool University Neuroleptic Side Effect Rating Scale (LUNSERS) or the Udvalg for Kliniske Undersogelser (UKU) Side Effect Rating Scale. Types of outcome measures / anticipated outcomes This review will include studies that quantitatively measure attitudes toward medication using standardised scales, such as the Drug Attitude Inventory (DAI). Attitudes toward medication refer to the patients’ perception towards different aspects of medication, including, but not limited to medication-taking, medication effects, and/or medication side effects.
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