The impact of anesthesia method on the severity of oxidative stress during coronary artery bypass grafting with cardiopulmonary bypass

Abstract

The objective : to investigate the impact of anesthesia method on the severity of oxidative stress in patients after coronary artery bypass grafting with cardiopulmonary bypass. Subjects and methods . Patients were randomized (seed 6556 as of 04.01.2016, www.randomization.com) to Volatile Induction and Maintenance Anesthesia ( VIMA ) with Sevoflurane group ( n = 65) and Total Intravenous Anesthesia with Propofol and Fentanyl ( TIVA ) group ( n = 66). The changes in oxidative stress markers in blood plasma were studied: carbonylated proteins, nitrotyrosine, oxidized forms of lo w-d ensity lipoproteins – ox y- L DL . Results . At the critical stage with 24 hours after the surgery, statistically significant differences in the carbonyls blood levels were found between VIMA with Sevoflurane and TIVA with Propofol groups: 0.88 (0.79–0.96) nmo l/m g protein (nmo l/m g) in TIVA group vs 0.81 (0.75–0.91) nmo l/m g in VIMA group, p = 0.01; and ox y- L DL levels 0.96 ± 0.40 m g/m l vs 0.83 ± 0.33 m g/m l, respectively, p = 0.04. Nitrotyrosine demonstrated no diagnostic value. Conclusion. It has been suggested that sevoflurane possesses antioxidant properties that can be regarded as a positive quality of VIMA in coronary artery bypass grafting with cardiopulmonary bypass.