Abstract
Background People with HIV/AIDS (PWHA) have higher risk of some cancers compared to the general population, with an approximately 2-fold increase for all non-AIDS-defining cancers (NADC). The widespread use of highly active antiretroviral therapy (HAART) has improved life expectancy of PWHA, exposing them to both aging and the prolonged exposure to cancer risk factors. A linkage study was therefore conducted to evaluate the impact of aging on the burden of cancer in this population.
Highlights
People with HIV/AIDS (PWHA) have higher risk of some cancers compared to the general population, with an approximately 2-fold increase for all non-AIDS-defining cancers (NADC)
Concerning specific cancer site/type, standardized incidence rates (IR) revealed an increase of liver and lung cancers
No significant variation across periods emerged for Hodgkin lymphoma (IRs: 83 and 69 per 100,000 in pre- and highly active antiretroviral therapy (HAART) period; IR ratio: 0.8, 95% CI: 0.5-1.3)
Summary
People with HIV/AIDS (PWHA) have higher risk of some cancers compared to the general population, with an approximately 2-fold increase for all non-AIDS-defining cancers (NADC). The widespread use of highly active antiretroviral therapy (HAART) has improved life expectancy of PWHA, exposing them to both aging and the prolonged exposure to cancer risk factors. A linkage study was conducted to evaluate the impact of aging on the burden of cancer in this population
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