Abstract
Objectives To investigate whether acute atrial fibrillation (AF) creates a prothrombotic state in hypertensive patients, and to assess the evolution in research indices after cardioversion. Design and methods Plasma levels of von Willebrand factor (vWf), soluble P-selectin and fibrin D-dimers were measured in hypertensive patients with acute AF pre-cardioversion and at 1, 7, 14, and 30 days post-cardioversion. The results were compared with hypertensive controls and healthy controls. Results Pre-cardioversion plasma vWf levels in acute AF patients were similar to those of controls; however, post-cardioversion, the vWf levels increased significantly and only returned to baseline levels 14 days later. Compared with controls, acute AF patients had higher levels of fibrin D-dimers, which lasted at least 14 days after cardioversion. Conclusions This study demonstrated that hypertensive patients with acute AF have an abnormal prothrombotic state, which persists for up to 14 days after cardioversion.
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