Abstract
The agglutinin response of four groups of goats inoculated with Brucella melitensis vaccine 0, 1, 2 and 4 weeks following experimental infection with Trypanosoma congolense was compared with that in non-infected controls. Four weeks after vaccination the goats were treated with a trypanocidal drug and the recovery of the immune response observed. The results indicated that the majority of animals had a significantly but not completely suppressed antibody response. This was most marked in the group vaccinated 2 weeks post-infection, which corresponded with the onset of parasitaemia. Although the mortality rate in the infected goats was high the titre in those remaining animals that were treated with the trypanocidal drug increased immediately after treatment. The possible implications of trypanosome induced immunosuppression for vaccination programmes in goats are discussed briefly.
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