Abstract
Objectives: Besides peripheral insulin resistance the decrease in beta-cell mass has been shown to play a crucial role in the pathogenesis of diabetes type 2. Cyclosporin A is a powerful immunosuppressive drug but its therapeutic use is limited by a number of untoward effects, among them hyperglycemia. Blocking of calcineurin phosphatase activity leading to an inhibition of stimulated insulin gene transcription is likely to contribute to the diabetogenic action of cyclosporin A. Previous results indicated that the dual leucine zipper bearing kinase is a calcineurin-sensitive kinase. In the present study the effect of cyclosporin A and of DLK on beta-cell survival was investigated.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Experimental and Clinical Endocrinology & Diabetes
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
