Abstract
Aim. This research was performed to study the specific immunoprophylaxis of rotavirus infection among child population in Krasnodar.Materials and methods. There was conducted the analysis of 2386 medical records of patients who were immunized against the rotavirus infection by the pentavalent reassortant vaccine "Rotatec" for the period of 2013-2017, the assessment of the incidence of acute intestinal infections (AII) and rotavirus infection among vaccinated and unvaccinated children of the first two years of life as well as a comparative analysis of primary prophylaxis of rotavirus infection with the incidence of rotavirus infection according to data of Rospotrebnadzor for the study period.Results. Coverage of the vaccination against rotavirus infection among children in Krasnodar for the period of 2013−2017 was 5,6 % of the target cohort which is not enough to reduce the incidence of rotavirus gastroenteritis. There was demonstrated the efficacy and safety of rotavirus vaccine. During the study period vaccinated children were 2.5 times less likely to suffer from AII. No cases of rotavirus infection were reported among the vaccinated respondents.Conclusion. The leading role of rotavirus infection in severe forms of acute gastroenteritis in children of the first 5 years of life as well as the high efficiency of vaccine prophylaxis gives hope that vaccination against rotavirus infection will be included in the Russian national calendar of preventive vaccinations everywhere in the nearest future.
Highlights
There was conducted the analysis of 2386 medical records of patients who were immunized against the rotavirus infection by the pentavalent reassortant vaccine "Rotatec" for the period of 2013-2017, the assessment of the incidence of acute intestinal infections (AII) and rotavirus infection among vaccinated and unvaccinated children of the first two years of life as well as a comparative analysis of primary prophylaxis of rotavirus infection with the incidence of rotavirus infection according to data of Rospotrebnadzor for the study period
Coverage of the vaccination against rotavirus infection among children in Krasnodar for the period of 2013−2017 was 5,6 % of the target cohort which is not enough to reduce the incidence of rotavirus gastroenteritis
During the study period vaccinated children were 2.5 times less likely to suffer from AII
Summary
Федеральное государственное бюджетное образовательное учреждение высшего образования «Кубанский государственный медицинский университет». Изучить специфическую иммунопрофилактику ротавирусной инфекцией среди детского населения города Краснодара. Иммунизированных против ротавирусной инфекции пентавалентной реассортантной вакциной «РотаТек», оценка заболеваемости острыми кишечными инфекциями (ОКИ) и ротавирусной инфекцией среди вакцинированных и невакцинированных детей первых двух лет жизни, а также сравнительный анализ первичной профилактики ротавирусной инфекции с уровнем заболеваемости ротавирусной инфекцией по данным Роспотребнадзора за исследуемый период. Охват вакцинацией против ротавирусной инфекции среди детского населения в Краснодаре за период 2013−2017гг составил 5,6% целевой кагорты, что недостаточно для снижения уровня заболеваемости ротовирусными гастроэнтеритами. Ведущая роль ротавирусной инфекции при тяжелых формах острых гастроэнтеритов у детей первых 5 лет жизни, а также высокая эффективность вакцинопрофилактики, позволяет надеяться, что вакцинация против ротавирусной инфекции повсеместно будет включена в российский Национальный календарь профилактических прививок в ближайшем будущем. For citation: Sutovskaya D.V., Burlutskaya А.V., Dubova L.V, Tunikova E.I., Kulikova V.V. The immunoprophylaxis of rotavirus infections in Krasnodar.
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