Abstract
Background and Aim:The immunocompromised condition is considered a defect in the immune system. This condition tends to increase the risk of oral candidiasis, due to the inability of the immune system to eliminate the adhesion of Candida albicans and leads to systemic candidiasis with a mortality rate of 60%. Green tea (Camellia sinensis) contains potential antioxidant and immunomodulatory which acts as anticancer, antifungal, and antivirus agent. The aim of this study was to invent herbal-based medicine, which acts as an immunomodulator and antifungal agent to treat fungal infection in immunocompromised patients.Materials and Methods:Thirty-five immunocompromised Wistar rats induced with C. albicans were divided into 7 groups (n=5): Control group (C+); treated for 4 days with green tea extract 1.25% (GT 4), epigallocatechin gallate (EGCG) 1% (EGCG 4), EGC 1% (EGC 4); and treated for 7 days with green tea extract 1.25% (GT 7), EGCG 1% (EGCG 7), and EGC 1% (EGC 7). Tongue tissue was collected and analyzed with immunohistochemistry staining using monoclonal antibody; interleukin (IL)-17A, IL-8, and human beta-defensin 2 (HBD)-2. Data were analyzed using analysis of variance test and Tukey honest significant differences test.Results:The expression of IL-17A, IL-8, and HBD-2 was significantly increased (p=0.000) after green tea extract administration in 7 days, whereas in 7 days, the expression of IL-8, IL-17A, and HBD-2 after EGCG and EGC administration did not give a significant result (p>0.005).Conclusion:Within the limits of this study, green tea extract has the ability as an immunomodulatory agent in an immunocompromised patient infected by C. albicans through expression augmentation of IL-8, IL-17A, and HBD-2 compared to EGCG and EGC.
Highlights
The immune system is an essential mechanism to against microorganism and its toxins
Within the limits of this study, green tea extract has the ability as an immunomodulatory agent in an immunocompromised patient infected by C. albicans through expression augmentation of IL-8, IL-17A, and human beta-defensin 2 (HBD)-2 compared to epigallocatechin gallate (EGCG) and EGC
This study using 35 immunocompromised Wistar rats induced with C. albicans, which are divided into 7 groups (n=5): Control group (C+); treated with green tea extract concentration 1.25% for 4 (GT 4) and 7 (GT 7) days; EGCG 1% for 4 (EGCG 4) and 7 (EGCG 7) days; and treated EGC 1% for 4 (EGC 4) and 7 (EGC 7) days
Summary
The defect in the immune system could lead to an immunocompromised condition that put patients at high risk of various infections of fungal, viral, and bacterial infections [1]. One of the most common infection is fungal infection, oral candidiasis, which could lead to systemic candidiasis with a mortality rate of 60% [1,2]. The immunocompromised condition is considered a defect in the immune system This condition tends to increase the risk of oral candidiasis, due to the inability of the immune system to eliminate the adhesion of Candida albicans and leads to systemic candidiasis with a mortality rate of 60%. The aim of this study was to invent herbal-based medicine, which acts as an immunomodulator and antifungal agent to treat fungal infection in immunocompromised patients
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