Abstract
Introduction: Bacterial infection induces inflammation in human body. This process produceshumoral and cellular immune responses. Cinnamomum burmanii grows very vast in Indonesia and contains cinnamaldehyde known to have an anti-inflammatory effect. Objective : To prove the effect of C. burmanii bark extract on CRP level, leukocyte count and differential blood count. Methods: Aposttest-only controlled group design with 25 Wistar Rats divided into 5 groups was employed. The CN-G group was giventhe standard feed, the CP-G group was given the standard feed and levamisole 2.5 mg/KgBW, while the CBE-100, CBE-200, and CBE-400 groups were respectively given the standard feed and cinnamon bark extract 100 mg/kgBW, 200 mg/KgBW and 400 mg/KgBW. The treatmentswereconducted for 7 consecutive days.On day 8, all rats were injected with the suspense of S. aureus intraperitoneally. The blood wasthen drawn on day 9, followed with CRP level measurement using the ELISA method. The total leukocyte count and differential blood count weremanually measured. Results: There is no significant difference in the value of CRP level (One Way ANOVA; p = 0.749) with the total counts of leukocytes(p=0.685), monocytes (p=0.769), and eosinophil(p=0.123) between groups. The neutrophils and lymphocytes of CBE-100 group aresignificantly differentfrom the other groups. Conclusion: C. burmanii extract has a potential benefit as immunomodulator.
Highlights
Bacterial infection induces inflammation in human body
The groups were CN-G group given with the standard feed, CP-G group given with standard feed and levamisole 2.5 mg/kgBW, CBE-100 group given with standard feed and cinnamon extract 100 mg/kgBW, CBE-200 group given with standard feed and cinnamon extract 200 mg/kgBW and CBE-400 group given with standard feed and cinnamon extract 400 mg/kgBW
CN-G: Control Negative-Group; CP-G: Control Positive-Group; CBE-100: group administered with 100 mg/kgBB Cinnamomum burmanii; CBE-200: group administered with 200 mg/kgBB Cinnamomum burmanii CBE-400: group administered with 400 mg/ kgBB Cinnamomum burmani
Summary
Bacterial infection induces inflammation in human body. This process produces humoral and cellular immune responses. Objective: To prove the effect of C. burmanii bark extract on CRP level, leukocyte count and differential blood count. The blood was drawn on day 9, followed with CRP level measurement using the ELISA method. Monocytes, mastocytes, platelet and endothelial cells may produce proinflammatory cytokines as a response to inflammation. Interleukin-1 (IL 1), interleukin 6 (IL 6) and Tumor Necrosis Factor (TNF) alpha are cytokines released by macrophages and initiate an acute phase immune response. In this acute phase immune reaction, liver synthesizes a protein called CReactive Protein (CRP). The bond between CRP and phosphocholine on bacterial cell membrane will activate complement through the classical pathway (Sproston and Ashworth, 2018)
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