Abstract
The Immunology of Zoonotic Infections
Highlights
Zoonoses include diseases induced by diverse pathogens, but a common pattern for the majority of them is their complexity: this term refers to their ecology, range of clinical characteristics, and diagnostic and therapeutic challenges, but foremost to their immunology
Mitroulis focuses on another specific and increasingly recognized as important part of zoonotic pathophysiology, that of autophagic response in certain intracellular zoonoses, outlining how this autophagic machinery can be exploited by zoonotic pathogens, typically culminating in chronic infections
Oliveira et al is one of the papers in this special issue attempting to translate theoretical knowledge in experimental data: the authors demonstrate in a mice model how a particular cytokine receptor deficiency induces a specific default in immunity against Leishmania major that results in specific clinical manifestations
Summary
Zoonoses include diseases induced by diverse pathogens (bacteria, viruses, fungi, and parasites), but a common pattern for the majority of them is their complexity: this term refers to their ecology, range of clinical characteristics, and diagnostic and therapeutic challenges, but foremost to their immunology. All other ecological, clinical, diagnostic and therapeutic complexities emerge from this multifaceted zoonotic pathophysiology, as certain papers of this special issue outline.
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