Abstract
SummaryCell suspensions prepared from the avian thymus and bursa of Fabricius were tested for immunological competence by their ability to give graft versus host reactions, as assessed by the production of lesions on the chorioallantoic membrane of chick embryos. Thymic cell suspensions were more active than bursal cells by a mean factor of six.Bursal cell suspensions contained more plasma cells, and bursal extracts contained higher titres of a natural haemagglutinin than did thymic extracts.There was a greater uptake of the radioisotope 32P by bursal cells than by thymic cells, both in vivo and in vitro. After incubation in vitro with 3H‐thymidine, 20 per cent of bursal cells and 9 per cent of thymic cells were labelled.Transfusion of labelled bursal and thymic cells into young normal recipient chicks showed that more thymic cells “homed” to the spleen.The results are discussed in relation to the concept of a dissociation of immunological responsiveness in the chicken.
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