The Immunological Properties of Nanomaterials for Repairing Knee Ligament Sports Injuries

Abstract

With the development of science and the advancement of medicine, there are more and more treatment methods for repairing knee ligament sports injuries. At present, the common method of ligament repair is to implant artificial synthetic materials or natural biological materials into the body to form artificial ligaments to repair and reconstruct damaged ligaments. Existing ligament repair techniques are often accompanied by sequelae, and the implants are not well adapted. The purpose of this article is to compare the degree of repair of damaged ligaments after implantation of artificial ligaments made of different nanomaterials and to study the mechanical properties, biomechanical properties, and immunological properties of artificial ligaments implanted in the body, in order to explore the role of different artificial ligaments on knee ligament repair. According to the different synthetic materials of artificial ligaments, the experimental subjects were divided into three groups: silk fibroin polycaprolactone nanofiber membrane group (SF/PCL), polycaprolactone nanofiber membrane group (PCL), and control group. By comparing the biocompatibility, cell adhesion, cell proliferation rate, and repair ability of collagen fiber formation of the experimental scaffold after implantation in the body, as well as its immunological performance, the results of the study showed that compared with PCL, SF/PCL increased its biocompatibility by 25%, increased its cell proliferation by 57%, increased its somatic cell adhesion by 35%, and increased its collagen fiber formation by 12%, the porosity is about 60%, and the load is as high as 907 ± 132 N . The data shows that the silk fibroin polycaprolactone nanofiber membrane scaffold has good biocompatibility, degradability, and mechanical properties.