Abstract
Cholera toxin-stimulated fluid secretion by the ileum is believed to be mediated by an adenylate cyclase-cyclic AMP mechanism. Immunization against cholera toxin (CT) reduces CT binding to microvillus membranes and suppresses fluid secretion following CT challenge. The present study disclosed no alteration in the fluid absorption rates. However, suppression of fluid secretion occurred despite maximal stimulation of mucosal adenylate cyclase in immunized animals.
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