Abstract
Schistosoma mansoni infection has been associated with glomerulonephritis for decades. 1 Hoshino-Shimizu S. de Brito T. Kanamura H.Y. et al. Human schistosomiasis: Schistosoma mansoni antigen detection in renal glomeruli. Trans R Soc Trop Med Hyg. 1976; 70: 492-496 Google Scholar Among the patients who present with hepatic fibrosis, 10%–15% develop glomerular disorders. 2 Van Velthuysen M.L. Glomerulopathy associated with parasitic infections. Parasitol Today. 1996; 12: 102-107 Google Scholar Several types of glomerulopathy, including membranous nephropathy (MN), 3 Andrade Z.A. Rocha H. Schistosomal glomerulopathy. Kidney Int. 1979; 16: 23-29 Google Scholar have been observed. Immunopathologic data were gathered from 12 patients with MN from Brazilian academic institutions (Figure 1). The patients had a mean age of 47.8 ± 13.7 years, and 75% were male. Median proteinuria was 5.2 g/24 h (varying between 2.0 and 6.9 g/24 h) with a mean serum creatinine of 1.06 ± 0.39 mg/dl. Eleven patients (91.7%) showed positivity for IgG1, and 10 (83.3%) for IgG4 and PLA2R. IgG2 staining was negative in 11 cases and weak in a single patient. IgG3 and THSD7A staining was negative in all cases. Detection of circulating anti-PLA2R antibody could not be performed. This immunopathologic profile is suggestive of primary MN, which was unexpected in patients with chronic S. mansoni infection, as MN in this context was previously assumed to be secondary. Schistosoma mansoni-induced mesangiocapillary glomerulonephritis: Influence of therapyKidney InternationalVol. 35Issue 5PreviewSchistosoma mansoni-induced mesangiocapillary glomerulonephritis: Influence of therapy. Schistosomiasis mansoni has been well documented as one of the causes of infectious glomerulopathy, with mesangiocapillary glomerulonephritis being the most frequent lesion observed in this condition Twenty-one patients with hepatosplenic schistosomiasis mansoni and biopsy-documented mesangiocapillary glomerulonephritis (MCGN) were studied and compared with 19 patients with the idiopathic form of MCGN. Nephrotic syndrome was the most frequent clinical presentation in both groups. Full-Text PDF Open Archive
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