The Immunoglobulin profiling of Schistosoma mansoni infected patients from Central India

Abstract

Schistosoma mansoni ‐schistosomicimmune response in them. Also, an attempt was made to correlate the observedIg level with the brutality of infection. Consequently, total 138(46.9%) out of 294 volunteers were reported to have ova of Schistosomamansoni in their urine samples. Among which, 84 (28.6%) volunteers with<50 ova in per 10 ml of urine showed light infection while remaining 54(18.4%) volunteers with >50 ova in per 10 ml of urine showed heavy infection.This difference was found statistically significant (X 2= 6.52, p > 0.05).The mean immunoglobulin status observed in their serum sample were; IgE(2141.6 ± 143.7 mg/dL), IgG (13.6 ± 3.53 mg/dL), IgA (3.72 ± 0.149 mg/dL),IgM (2.82 ± 0.48 mg/dL) and IgD (0.12 ± 0.04 mg/dL). The relationship betweenintensity of infection and serum level of IgM & IgE were positivelycorrelated (r =0.27 and r =0.65, respectively) while IgG, IgA and IgD wereshowing negative correlation with the strength of infection (r = ‐0.65, r = ‐0.39 and r = ‐0.18, respectively). Therefore, IgG and IgA can be considered asmarkers of light infection and IgM and IgE for heavy infection respectively.Since, the levels of IgG, IgA and IgD were found very low in infected volunteersthan control subjects hence, are suggested to play insignificant protectiverole in schistosomic infection., a trematode is a significant parasite of human beingscausing intestinal schistosomiasis. In the present investigation, 294 volunteersfrom central India were screened for schistosomic infection, and theserum immunoglobulin (Ig) levels were calculated as an anti