Abstract
Studies (5-11) have proved that experimental tuberculosis in guinea pigs can be suppressed or prevented during the period of isoniazid pro phylaxis, but, when treatment is discontinued, a varying number of animals develop progres sive tuberculosis. It has been demonstrated (8) that a percentage of the animals which do not develop allergy (immunity) or show any ap preciable sign of tuberculous disease during an observation period of two years varies inversely with the size of the challenge, and directly with the duration of the treatment. This experiment was designed primarily to determine the degree of protection against tuberculosis in guinea pigs which were vacci
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