Abstract
Some may wonder why a comparative immunologist would knock on the door of the controversial field of complementary and alternative medicine (CAM). The field is replete with problems associated with beliefs, disbeliefs, shaky concepts and ill-defined experimental approaches at solving fundamental questions. Yet there is a measure of order in that miniscule, infinitesimal corner of phenomena that begs for clarification and solid attempts to create order from the chaos. Such was the world of comparative immunology in the early 60s when the parent field of immunology was budding into the giant sequoia of a discipline that it is today. There was essentially one model the eternal mouse whose spleen seemed to provide the essence of immunology! How did it all get started and how did that somewhat fortuitous birth provide succor for a field that could approach CAM. Entering CAM with an evidence-based approach was therefore as much of a fruitful and fulfilling challenge as trying to probe convincingly the existence of innate immunity in earthworms (1,2).
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