Abstract
Over the last 3 decades, our knowledge of the immune system has vastly increased. We now understand in detail the mechanism of phagocytosis and the intracellular cascade of antigenic processing. We know that exogenous and endogenous peptides link themselves to molecules unique to each individual, then emerge on the cellular surface to provide a specific activating signal when an infecting agent is encountered. Moreover, we are learning more about the diversity of adherence and contact molecules that allow intercellular communication. At the genetic level, molecular biologists have examined the immunoglobulin sequences and their variable regions, the processes of somatic recombination and hypermutation, and even the crystallographic panorama of the union of the antigen and antibody in order to understand how the humoral response operates. Work continues on the manipulation of monoclonal antibodies, cytokines, addressins, integrins, and growth factors, through the clinical use of recombinant technology. We stand on the threshold of a new era in the management of infections and autoimmune phenomena. Despite its complexity, the internal world of the human body becomes more accessible each day.
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