Abstract

10 patients with Crohn's disease in various states of activity have been injected with 3.3 times 10-9 plaque-forming units of the bacteriophage phi chi 174, as a test for their capacity to produce antibodies. 9 patients had a completely normal primary and secondary antibody response. One patient had higher levels of preimmunization antibodies than have been encountered in normal subjects and developed a secondary (IgG) response to the first dose of antigen. We conclude that there is no evidence of a general disturbance of antibody-producing capacity in subjects with Crohn's disease.

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