Abstract
The identification of the Rous virus; a morphological and biological study.
Highlights
MethodsThe ascites form of this strain of the Rous sarcoma showed an intermittent tendency to grow in solid masses in the peritoneum and 12 fluid transplant generations were the most that could be achieved
Experiments are described which were performed to establish the presence of virus-like particles 70 m,t. in diameter in the tumour cells of an ascites form of the Rous sarcoma, the site of the particles in the cells, and the incidence of cells with particles in the tumour cell population
A method of preparing ascites cells for electron microscopy has been used which allows all the cells in a given sample to be examined, as well as the whole of each cell; nearly 13,000 cells from 8 Rous ascites tumours were searched in the electron microscope in this part of the work
Summary
The ascites form of this strain of the Rous sarcoma showed an intermittent tendency to grow in solid masses in the peritoneum and 12 fluid transplant generations were the most that could be achieved On account of this tendency to solid growth new Rous ascites tumour lines were started on several occasions in the course of the work. Animals.-Pedigreed susceptible Brown Leghorn fowl from the Poultry Research Centre, Edinburgh, were used for the tumour passages and for the titrations. They were between 7 and 101 weeks old when inoculated, with the exception of one bird aged 1 1 weeks and one aged 121. The age at which the birds were used was determined by the exigencies of supply
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