Abstract
The mechanism of the hypoglycaemic effect of the monoamine oxidase inhibitor mebanazine (Actomol) on the blood sugar has been studied in rats. Hypoglycaemia started as late as 4 to 8 hr after single injections of mebanazine, but continued for several days. Mebanazine does not affect the activity of glucose-6-phosphatase, but slightly intensifies the activity of the phosphorylase system of the liver. It causes hypoglycaemia in adrenalectomized rats, too. Mebanazine also reduces the blood glucose level in animals which receive simultaneously thyroxin, triiodothyronine or hydrocortisone. Mebanazine when injected simultaneously with adrenalin does not interfere with the hyperglycaemic effect of the latter. The combined effect of mebanazine and insulin in reducing the blood glucose level is greater than tne total sum of the individual effects when the drugs are given separately (augmentative synergism). Thus it becomes obvious that mebanazine potentiates the effect of insulin.
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